| Synthesis
Formats |
- Solution-phase
- Solution-phase
using solid-phase reagents or scavengers
- Solid-phase
|
| Synthesis
Capabilities |
- Serial
- Parallel
- Combinatorial
- Microwave
|
| Analysis,
Purification and Compound Management Capabilities |
- High-throughput
analytical-scale RP HPLC/photodiode array UV/HRMS
- High-throughput
mass-directed preparative-scale RP HPLC/dual-wavelength
UV/LRMS/ELSD
- Medium-throughput,
automated, 5mm tube-based 1H and 13C NMR
- Compound
formatting available in a variety of formats (vials, plates)
and solvents
|
| Cheminformatics
Capabilities |
- Virtual
compound library enumeration and screening
- In silico
property calculation, including ADME, toxicology, and metabolic
profiling
- Pharmacophore
perception and docking
- Hit
clustering and data mining
- 1D/2D/3D
QSAR including COMFA, COMBINE
|
| Center-Driven
Project Capabilities |
- Target
identification and localization using affinity labeling
of probe compounds
- Yeast
three-hybrid systems as tools for identification of protein
targets of probe compounds
|
| Biological/Medicinal
Chemistry Expertise |
- Analog
design
- Anti-infectives
- Cancer
- Cell
permeation
- Central
nervous system
- Natural
products chemistry
- Nuclear
receptor system
- Opioids
- Proteases
|
